West Nile Virus in a Pregnant Woman with Acquired Immune Deficiency Syndrome

Karli Boggs, MD, Louise McLaughlin, MS, MPS, Ferney Moore, MD Andrew Montz, MD


BACKGROUND: To the best of our knowledge, this is the first reported case of a pregnant, human immunodeficiency virus (HIV) positive, acquired immunodeficiency deficiency (AIDS) patient with neuro-invasive West Nile Virus (WNV).  The symptoms of WNV infection may be attributed to other central nervous system (CNS) syndromes associated with HIV/AIDS, and a definitive diagnosis of WNV infection can be delayed, making the challenges associated with this patient of interest to the medical community.

CASE: A 24-year-old pregnant patient with AIDS presented with a headache, nausea, vomiting, non-bloody diarrhea, and fever. During hospitalization, she became increasingly lethargic and somnolent. She endorsed mosquito bites three days prior to her hospitalization and her symptoms resolved with supportive measures. Cerebrospinal fluid was positive for West Nile IgM and IgG antibodies.

CONCLUSION: WNV infection should be considered in the differential diagnosis of pregnant HIV/AIDS patients with CNS symptomology, especially in endemic areas.

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